解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Randomized controlled trials are the gold-standard for clinical trials. However, randomization is not always feasible. In this article we propose a prospective and adaptive matched case-control trial design assuming that a control group already exists. METHODS:We propose and discuss an interim analysis step...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0763-3
更新日期:2019-07-16 00:00:00
abstract:BACKGROUND:The study design and protocol that underpin a randomised controlled trial (RCT) are critical for the ultimate success of the trial. Although RCTs are considered the gold standard for research, there are multiple threats to their validity such as participant recruitment and retention, identifying a meaningful...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0772-2
更新日期:2019-06-18 00:00:00
abstract:BACKGROUND:Cluster randomised trials with unequal sized clusters often have lower precision than with clusters of equal size. To allow for this, sample sizes are inflated by a modified version of the design effect for clustering. These inflation factors are valid under the assumption that randomisation is stratified by...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0760-6
更新日期:2019-06-14 00:00:00
abstract:BACKGROUND:Small group research in healthcare is important because it deals with interaction and decision-making processes that can help to identify and improve safer patient treatment and care. However, the number of studies is limited due to time- and resource-intensive data processing. The aim of this study was to e...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0756-2
更新日期:2019-06-13 00:00:00
abstract:BACKGROUND:The likelihood ratio function (LR), the ratio of conditional probabilities of obtaining a specific marker value among those with the event of interest over those without, provides an easily interpretable way to quantify the update of the risk prediction due to the knowledge of the marker value. The LR has be...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0721-0
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Studies in both paediatric and psychiatric settings often experience problems in recruitment. This can compromise the ability of the study to recruit to target, meaning studies are potentially underpowered. It can also result in a biased sample if a non-representative group are selectively recruited. Recruit...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0730-z
更新日期:2019-04-27 00:00:00
abstract:BACKGROUND:Measuring body mass index (BMI) has been proposed as a method of screening for preventive primary care and population surveillance of childhood obesity. However, the accuracy of routinely collected measurements has been questioned. The purpose of this study was to assess the reliability of height, length and...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0726-8
更新日期:2019-04-24 00:00:00
abstract:BACKGROUND:Crowding in the emergency department (ED) is associated with increased mortality, increased treatment cost, and reduced quality of care. Crowding arises when demand exceed resources in the ED and a first sign may be increasing waiting time. We aimed to quantify predictors for departure from the ED, and relat...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0710-3
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:In clinical trials, study designs may focus on assessment of superiority, equivalence, or non-inferiority, of a new medicine or treatment as compared to a control. Typically, evidence in each of these paradigms is quantified with a variant of the null hypothesis significance test. A null hypothesis is assume...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0699-7
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:Navigating the world of qualitative thematic analysis can be challenging. This is compounded by the fact that detailed descriptions of methods are often omitted from qualitative discussions. While qualitative research methodologies are now mature, there often remains a lack of fine detail in their descriptio...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0707-y
更新日期:2019-03-28 00:00:00
abstract:BACKGROUND:Surveys are established methods for collecting population data that are unavailable from other sources; however, response rates to surveys are declining. A number of methods have been identified to increase survey returns yet response rates remain low. This paper evaluates the impact of five selected methods...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0702-3
更新日期:2019-03-20 00:00:00
abstract:BACKGROUND:A strong need exists for a validated tool that clearly defines peer review report quality in biomedical research, as it will allow evaluating interventions aimed at improving the peer review process in well-performed trials. We aim to identify and describe existing tools for assessing the quality of peer rev...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0688-x
更新日期:2019-03-06 00:00:00
abstract:BACKGROUND:Recruitment to clinical trials can be challenging. Methods that improve the efficiency of trial recruitment are needed to increase successful study completions. The aim of this study was to ascertain whether sending an audio-visual presentation on a digital versatile disc (DVD), along with usual study invita...
journal_title:BMC medical research methodology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12874-019-0663-6
更新日期:2019-01-30 00:00:00
abstract:BACKGROUND:Within cancer care, dynamic evaluations of the loss in expectation of life provides useful information to patients as well as physicians. The loss of lifetime function yields the conditional loss in expectation of life given survival up to a specific time point. Due to the inevitable censoring in time-to-eve...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0661-8
更新日期:2019-01-28 00:00:00
abstract:BACKGROUND:Spiritual care is defined as recognizing and responding to the needs of the human spirit when the individual is facing trauma, illness, or sadness. Providing spiritual care is one of the core aspects of holistic care, as it is significantly associated with patients' quality of life. The provision of optimal ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0662-7
更新日期:2019-01-23 00:00:00
abstract:BACKGROUND:Mean arterial pressure (MAP), bispectral index (BIS), and minimum alveolar concentration (MAC) represent valuable, yet dynamic intraoperative monitoring variables. They provide information related to poor outcomes when considered together, however their collective behavior across time has not been characteri...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-019-0660-9
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:Standard random-effects meta-analysis methods perform poorly when applied to few studies only. Such settings however are commonly encountered in practice. It is unclear, whether or to what extent small-sample-size behaviour can be improved by more sophisticated modeling. METHODS:We consider likelihood-based...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0618-3
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:In order to accurately measure and monitor levels of moderate-to-vigorous physical activity (MVPA) and sedentary behaviour (SB) in older adults, cost efficient and valid instruments are required. To date, the International Physical Activity Questionnaire (IPAQ) has not been validated with older adults (aged ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,多中心研究
doi:10.1186/s12874-018-0642-3
更新日期:2018-12-22 00:00:00
abstract:BACKGROUND:Multi-centre randomized controlled clinical trials play an important role in modern evidence-based medicine. Advantages of collecting data from more than one site are numerous, including accelerated recruitment and increased generalisability of results. Mixed models can be applied to account for potential cl...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0602-y
更新日期:2018-11-29 00:00:00
abstract:BACKGROUND:We demonstrate an application of Group-Based Trajectory Modeling (GBTM) based on the beta distribution. It is offered as an alternative to the normal distribution for modeling continuous longitudinal data that are poorly fit by the normal distribution even with censoring. The primary advantage of the beta di...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0620-9
更新日期:2018-11-26 00:00:00
abstract:BACKGROUND:Family members are increasingly involved in the care of cancer patients, however many are not prepared for this challenging role. Intervention-based studies are valuable to inform the most appropriate and effective support for caregivers. Barriers in the recruitment of patient/caregiver dyads exist but the r...
journal_title:BMC medical research methodology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12874-018-0614-7
更新日期:2018-11-21 00:00:00
abstract::Clinical Decision Support Systems (CDSS) provide aid in clinical decision making and therefore need to take into consideration human, data interactions, and cognitive functions of clinical decision makers. The objective of this paper is to introduce a high level reference model that is intended to be used as a foundat...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0587-6
更新日期:2018-11-16 00:00:00
abstract:BACKGROUND:Diet plays an important role in chronic disease, and the use of dietary pattern analysis has grown rapidly as a way of deconstructing the complexity of nutritional intake and its relation to health. Pattern analysis methods, such as principal component analysis (PCA), have been used to investigate various di...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0585-8
更新日期:2018-10-29 00:00:00
abstract:BACKGROUND:To provide empirical evidence about prevalence, reporting and handling of missing outcome data in systematic reviews with network meta-analysis and acknowledgement of their impact on the conclusions. METHODS:We conducted a systematic survey including all published systematic reviews of randomized controlled...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0576-9
更新日期:2018-10-24 00:00:00
abstract:BACKGROUND:Polypharmacy can be either beneficial or harmful to children. We conducted a scoping review to examine the concept of pediatric polypharmacy: its definition, prevalence, extent and gaps in research. In this manuscript, we report our transdisciplinary scoping review methodology. METHODS:After establishing a ...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0560-4
更新日期:2018-10-04 00:00:00
abstract:BACKGROUND:The lack of suitable and reliable scales to measure self-reported health and health behaviour among people with intellectual disabilities (ID) is an important methodological challenge in health research. This study, which was undertaken together with co-researchers with ID, explores possibilities for self-re...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0539-1
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:Multilevel models for non-normal outcomes are widely used in medical and health sciences research. While methods for interpreting fixed effects are well-developed, methods to quantify and interpret random cluster variation and compare it with other sources of variation are less established. Random cluster va...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0517-7
更新日期:2018-07-06 00:00:00
abstract:BACKGROUND:Few studies have compared methods to correct for retest effects or practice effects in settings where an acute event could influence test performance, such as major surgery. Our goal in this study was to evaluate the use of different methods to correct for the effects of practice or retest on repeated test a...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0530-x
更新日期:2018-07-03 00:00:00
abstract:BACKGROUND:Motivational Interviewing (MI), Brief Advice (BA) and Health Education (HE) are established smoking cessation induction methods for smokers with low desire to quit. Although randomized controlled trials (RCT's) have been frequently used to assess these interventions the temporal efficacy and effectiveness of...
journal_title:BMC medical research methodology
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12874-018-0511-0
更新日期:2018-06-13 00:00:00
abstract:BACKGROUND:In many studies the information of patients who are dying in the hospital is censored when examining the change in length of hospital stay (cLOS) due to hospital-acquired infections (HIs). While appropriate estimators of cLOS are available in literature, the existence of the bias due to censoring of deaths w...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0500-3
更新日期:2018-05-30 00:00:00
abstract:BACKGROUND:When discussing results medical research articles often tear substantive and statistical (methodical) contributions apart, just as if both were independent. Consequently, reasoning on bias tends to be vague, unclear and superficial. This can lead to over-generalized, too narrow and misleading conclusions, es...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/s12874-018-0490-1
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:Many biological variables sampled from human subjects show a diurnal pattern, which poses special demands on the techniques used to analyze such data. Furthermore, most biological variables belong to nonlinear dynamical systems, which may make linear statistical techniques less suitable to analyze their dyna...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0485-y
更新日期:2018-03-21 00:00:00
abstract:BACKGROUND:Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a rare disease with extreme between-subject variability, especially with respect to rate of disease progression. This makes modelling a subject's disease progression, which is measured by the ALS Functional Rating Scale (ALSFRS), ver...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0479-9
更新日期:2018-02-06 00:00:00
abstract:BACKGROUND:Defeat and entrapment have been shown to be of central relevance to the development of different disorders. However, it remains unclear whether they represent two distinct constructs or one overall latent variable. One reason for the unclarity is that traditional factor analytic techniques have trouble estim...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-018-0470-5
更新日期:2018-01-25 00:00:00
abstract:BACKGROUND:The Template for Intervention Description and Replication (TIDieR) checklist and guide was developed by an international team of experts to promote full and accurate description of trial interventions. It is now widely used in health research. The aim of this paper is to describe the experience of using TIDi...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-017-0461-y
更新日期:2018-01-18 00:00:00
abstract:BACKGROUND:The reporting of randomised controlled trial (RCT) abstracts is of vital importance. The primary objective of this study was to investigate the association between structure format and RCT abstracts' quality of methodology reporting, informed by the current requirement and usage of structure formats by leadi...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-017-0469-3
更新日期:2018-01-10 00:00:00
abstract:BACKGROUND:Diagnostic tests are performed in a subset of the population who are at higher risk, resulting in undiagnosed cases among those who do not receive the test. This poses a challenge for estimating the prevalence of the disease in the study population, and also for studying the risk factors for the disease. ME...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-017-0447-9
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:There are detailed reviews about different recruitment strategies, but not with regard to differences between recruitment of hospital-based versus office-based physicians. Within this study, the two different recruitment schemes are compared. Advantages and disadvantages of different ways of recruitment in r...
journal_title:BMC medical research methodology
pub_type: 杂志文章
doi:10.1186/s12874-017-0425-2
更新日期:2017-11-22 00:00:00
abstract:BACKGROUND:The use of health-related quality of life (HRQoL) as an endpoint in cancer clinical trials is growing rapidly. Hence, research into the statistical approaches used to analyze HRQoL data is of major importance, and could lead to a better understanding of the impact of treatments on the everyday life and care ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/s12874-017-0410-9
更新日期:2017-09-26 00:00:00
abstract:BACKGROUND:Longitudinal studies using data collected as part of usual care risk providing biased results if visit times are related to the outcome of interest. Statistical methods for mitigating this bias are available but rarely used. This lack of use could be attributed to a lack of need or to a lack of awareness of ...
journal_title:BMC medical research methodology
pub_type: 杂志文章,评审
doi:10.1186/s12874-017-0418-1
更新日期:2017-09-06 00:00:00